Parkinson’s Disease

Neurodegeneration: Motor and Temporal Preparation in Parkinson’s Disease 

Parkinson’s Disease (PD) is a common cause of disability later in life. In addition to problem with motor functions, individuals with PD are known to have problems judging temporal intervals. In this study, our aim is to understand whether individuals with PD are also impaired in using temporal regularities present in the environment to enhance performance.

Experimental Approach

Using behavioural tasks combined with MEG and fMRI, we will measure changes in motor and temporal preparation to understand what brain mechanisms contribute to deficits in each of these domains. The study is part of the Cognitive Health in Ageing programme, funded by the National Institute for Health Research (NIHR) as part of the Oxford Biomedical Research Centre.

Translation

Neural and behavioural measures will be combined with measures of neuropsychological functioning and of muscle activity obtained while participants are performing the task. Our findings will aid understanding of the relationship between brain activity and the cognitive and motor difficulties in Parkinson’s disease. In addition to contributing to the understanding of how motor and cognitive functions are altered in this disease, we also hope to explore whether neural measures in these simple tasks can contribute to the development of effective biomarkers for the disorder.

Investigators and Collaborators 

Lab members contributing to the research are Kia Nobre (principal investigator), Simone Heideman (doctoral student), Joshua Chauvin (doctoral student), and Malcolm Proudfoot (doctoral student). The study is run in close collaboration with Clare Mackay (Psychiatry), Michele Hu (NDCN), Ricarda Menke (FMRIB), and Michal Rolinski (NDCN).

Funding 

The study is part of the Cognitive Health in Ageing programme, funded by the National Institute for Health Research (NIHR) as part of the Oxford Biomedical Research Centre.

Related Web Links: 

http://www.oxdare.ox.ac.uk/cognitive-health-in-ageing-cha